Research
Micronutrients & recovery
Omega-3 PUFA supplementation reduces total mortality and cardiovascular-related hospitalizations in patients with chronic heart failure with reduced ejection fraction.
If you have heart failure with a weak heart pump (reduced ejection fraction), taking fish oil supplements may help you live longer and avoid hospitalizations. It is a reasonable addition to your treatment plan. Ask your doctor if it's right for you.
ModerateSupportsMEDIUM confidence
These findings suggest that omega-3 PUFA supplementation may reduce heart failure–related hospitalizations and death in patients with heart failure with reduced ejection fraction. Although based on a single, large RCT, treatment with omega-3 PUFA supplements is reasonable among patients with heart failure with reduced ejection fraction (Class IIa Recommendation).
Why this rating
Based on a single large RCT (GISSI-HF).
Source
Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease
David S. Siscovick et al. · Circulation · 2017
DOI 10.1161/cir.0000000000000482
clinical_guidelineCited 621×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Omega-3 polyunsaturated fatty acid (EPA+DHA) supplementation does not reduce the risk of cardiovascular events or mortality in patients with diabetes mellitus or prediabetes.Good
- Omega-3 PUFA supplementation reduces coronary heart disease (CHD) death and possibly sudden cardiac death (SCD) in patients with prior clinical CHD, but does not reduce nonfatal myocardial infarction.Good
- Omega-3 PUFA supplementation does not reduce the risk of stroke (ischemic or hemorrhagic) in primary or secondary prevention settings.Good
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