Research
Micronutrients & recovery
Both HyD and Vitamin D3 suppress markers of innate immunity, but HyD causes a significantly more pronounced suppression of specific inflammatory markers (eotaxin, IL-12, MCP-1, MIP-1b) due to its rapid elevation of 25(OH)D levels.
Both forms of Vitamin D reduce inflammation, but HyD does so more effectively for certain markers. If managing inflammation is a priority, HyD may offer a faster or stronger anti-inflammatory effect than standard Vitamin D3.
ModerateQualifiesMEDIUM confidence
Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 b.
Why this rating
Small sample size, but multiple repeated measures and specific biomarker analysis.
Source
Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity
Heike A. Bischoff‐Ferrari et al. · Journal of Bone and Mineral Research · 2011
DOI 10.1002/jbmr.551
rct · n=20Cited 194×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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