Research
Mixed
Single oral doses of 150–900 mg naringenin (from whole orange extract) are safe and well-tolerated in healthy adults, with serum concentrations proportional to the dose.
Taking 300mg of naringenin (from a whole orange extract) twice daily is predicted to reach effective levels (8 μM) in your body to potentially support metabolic health, and it is safe to do so. You cannot get these levels from drinking orange juice alone.
GoodSupportsHIGH confidence
Ingestion of 150 to 900 mg doses of naringenin is safe in healthy adults, and serum concentrations are proportional to the dose administered.
Why this rating
Randomized, controlled, single-ascending-dose clinical trial in healthy adults (n=18), though small sample size.
Source
Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial
Candida J. Rebello et al. · Diabetes Obesity and Metabolism · 2019
DOI 10.1111/dom.13868
crossover · n=18Cited 141×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
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