Research
Energy balance
Naringenin delivered in whole orange extract achieves serum concentrations (Cmax ~48 μM at 600mg) that exceed the 8-10 μM threshold required to stimulate thermogenic gene expression (UCP1, GLUT4) in human adipocytes.
To potentially boost metabolism and insulin sensitivity, you may need to take 300mg of naringenin extract twice a day, as eating oranges won't provide enough of the active compound.
ModerateConditionalMEDIUM confidence
Since naringenin (8 μM) is effective in primary human adipocytes, ingestion of 300 mg naringenin twice/d will likely elicit a physiological effect.
Why this rating
Direct human efficacy data is not in this paper; it relies on in vitro adipocyte data (Ref 9) and PK extrapolation.
Source
Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial
Candida J. Rebello et al. · Diabetes Obesity and Metabolism · 2019
DOI 10.1111/dom.13868
crossover · n=18Cited 141×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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