Research
Hormonal
An isocaloric ketogenic diet decreases insulin-mediated antilipolysis (the ability of insulin to suppress fat breakdown) compared to a baseline diet, regardless of the meal consumed.
On a ketogenic diet, your body's fat cells become less responsive to insulin's signal to stop breaking down fat. This means insulin is less effective at suppressing fat release, even if your blood sugar control remains stable. This is a key metabolic shift to understand when managing body composition on keto.
GoodSupportsHIGH confidence
Insulin-mediated antilipolysis was decreased on the KD regardless of meal type.
Why this rating
Controlled inpatient study with detailed metabolic calculations (Belfiore Index, ADIPO-IR).
Source
Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet
Michael Rosenbaum et al. · Obesity · 2019
DOI 10.1002/oby.22468
crossover · n=17Cited 104×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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