Mixed
In patients with type 2 diabetes or prediabetes and established cardiovascular risk, maintaining a BMI of 25–35 kg/m² (overweight to mild obesity) is associated with lower all-cause and cardiovascular mortality compared to a normal BMI of 22–24.9 kg/m².
If you have diabetes or prediabetes along with other heart disease risks, do not aggressively pursue weight loss to reach a 'normal' BMI (22-25). Your data suggests you are safest in the overweight to mild obesity range (BMI 25-35). Focus on cardiovascular health markers rather than the scale number.
The lowest mortality risk was seen in patients with overweight and moderate obesity (BMI 25–35 kg/m2).
Why this rating
Large randomized trial (ORIGIN, N=12,521) with long follow-up (6.2 years) and multivariable adjustment, though observational in nature regarding BMI categories.
Source
Obesity and weight loss are inversely related to mortality and cardiovascular outcome in prediabetes and type 2 diabetes: data from the ORIGIN trial
Wolfram Doehner et al. · European Heart Journal · 2020
DOI 10.1093/eurheartj/ehaa293
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →