Research
Mixed
Sustained weight loss (defined as >1 kg/year over 2 years) is an independent risk factor for higher all-cause and cardiovascular mortality in patients with diabetes/prediabetes and CV risk, compared to maintaining stable weight.
If you have diabetes and heart disease risks, do not try to lose weight. If you have lost weight, do not try to lose more. Your goal should be to stabilize your weight. Aggressive weight loss strategies may increase your risk of death.
GoodRefutesHIGH confidence
A continued 2-year weight loss was associated with higher risk of mortality [HR 1.32 (1.18–1.46), P < 0.0001] and CV mortality [HR 1.18 (1.02–1.35), compared to patients without weight loss, P < 0.05].
Why this rating
Large RCT data with long follow-up and rigorous adjustment for confounders.
Source
Obesity and weight loss are inversely related to mortality and cardiovascular outcome in prediabetes and type 2 diabetes: data from the ORIGIN trial
Wolfram Doehner et al. · European Heart Journal · 2020
DOI 10.1093/eurheartj/ehaa293
rct · n=12521Cited 97×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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