Research
Hormonal
Resistance training induces 'anabolic resistance' in older adults, characterized by lower muscle protein synthesis rates in response to protein feeding and exercise compared to younger individuals.
Older adults experience 'anabolic resistance,' meaning their muscles respond less strongly to protein and exercise than younger people's. To overcome this, older adults may need higher protein intakes and more consistent resistance training to stimulate muscle growth.
GoodSupportsHIGH confidence
In comparison to younger persons older persons have a lower MPS rates in response to protein feeding and exercise (5, 13, 17), a condition termed 'anabolic resistance' (5).
Why this rating
Cited as a well-established phenomenon with multiple references.
Source
What is the relationship between the acute muscle protein synthesis response and changes in muscle mass?
Cameron J. Mitchell et al. · Journal of Applied Physiology · 2014
DOI 10.1152/japplphysiol.00609.2014
narrative_reviewCited 62×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Acute muscle protein synthesis (MPS) response to resistance exercise is not quantitatively correlated with long-term muscle hypertrophy in individuals, meaning acute MPS measurements cannot predict individual hypertrophic outcomes.Good
- Acute muscle protein synthesis measurements are useful for understanding mechanistic differences between exercise and nutritional interventions but are not sufficient to predict individual hypertrophic responses.Good
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