Research
Mixed
Acute muscle protein synthesis measurements are useful for understanding mechanistic differences between exercise and nutritional interventions but are not sufficient to predict individual hypertrophic responses.
Use acute MPS data to compare the *potential* of different training or nutritional strategies (e.g., milk vs. soy), but do not use it to predict how much muscle a specific person will gain.
GoodQualifiesHIGH confidence
Acute measurements of MPS response can provide important insight into the mechanistic underpinnings of divergent exercise and nutritional manipulations... at an individual level a divergent acute response in MPS may be necessary but is not sufficient to conclude that a divergent muscle hypertrophic response will follow
Why this rating
Synthesis of multiple studies.
Source
What is the relationship between the acute muscle protein synthesis response and changes in muscle mass?
Cameron J. Mitchell et al. · Journal of Applied Physiology · 2014
DOI 10.1152/japplphysiol.00609.2014
narrative_reviewCited 62×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Acute muscle protein synthesis (MPS) response to resistance exercise is not quantitatively correlated with long-term muscle hypertrophy in individuals, meaning acute MPS measurements cannot predict individual hypertrophic outcomes.Good
- Resistance training induces 'anabolic resistance' in older adults, characterized by lower muscle protein synthesis rates in response to protein feeding and exercise compared to younger individuals.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →