Mixed
Acute muscle protein synthesis (MPS) response to resistance exercise is not quantitatively correlated with long-term muscle hypertrophy in individuals, meaning acute MPS measurements cannot predict individual hypertrophic outcomes.
Do not use acute muscle protein synthesis tests to predict your muscle growth potential. While MPS is necessary for growth, its acute magnitude does not predict how much muscle you will gain from training. Focus on consistent training volume and nutrition rather than trying to maximize acute MPS spikes.
In neither study was a linear correlation between MPS and hypertrophy observed... the acute MPS response is not correlated with muscle hypertrophy after RT in the same individuals
Why this rating
Based on a viewpoint paper citing multiple primary studies (Refs 14, 15) showing lack of correlation.
Source
What is the relationship between the acute muscle protein synthesis response and changes in muscle mass?
Cameron J. Mitchell et al. · Journal of Applied Physiology · 2014
DOI 10.1152/japplphysiol.00609.2014
More from this paper
- Resistance training induces 'anabolic resistance' in older adults, characterized by lower muscle protein synthesis rates in response to protein feeding and exercise compared to younger individuals.Good
- Acute muscle protein synthesis measurements are useful for understanding mechanistic differences between exercise and nutritional interventions but are not sufficient to predict individual hypertrophic responses.Good
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →