Mixed
In individuals with type 2 diabetes, a history of cardiovascular disease and higher baseline BMI are associated with modestly poorer cognitive function following an intensive lifestyle intervention compared to standard care.
For individuals with type 2 diabetes who are obese or have a history of cardiovascular disease, intensive lifestyle interventions may not improve cognitive function and could be associated with modestly poorer outcomes compared to standard care. These individuals should discuss potential risks and benefits with their healthcare provider.
There was some evidence of trends for differential intervention effects showing modest harm in ILI in participants with greater body mass index and in individuals with a history of cardiovascular disease.
Why this rating
Subgroup analysis of a large RCT; trends were observed but not definitive for all domains.
Source
Effect of a Long‐Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study
Stephen R. Rapp et al. · Journal of the American Geriatrics Society · 2017
DOI 10.1111/jgs.14692
Related findings · Mixed
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