Hormonal
Phentermine/Topiramate Extended-Release (PHEN/TPM ER) produces greater mean weight loss (up to 10.9%) compared to other pharmacotherapies and placebo when used at the highest dose (15/92 mg).
If lifestyle changes aren't enough, ask your doctor about Phentermine/Topiramate. It requires a slow titration over several months to minimize side effects. The highest dose can lead to nearly 11% weight loss. You must stop if you don't lose at least 3-5% after 12 weeks, as it won't work for you. Avoid if pregnant or with certain eye/thyroid conditions.
Two randomized clinical trials... showed a mean weight loss of 9.8% to 10.9% for the 15/92-mg dose... compared with 1.2% to 1.6% in patients receiving placebo
Why this rating
Supported by randomized clinical trials (EQUIP, CONQUER) cited in the paper.
Source
Treatment of the Obese Patient in Primary Care: Targeting and Meeting Goals and Expectations
George A. Bray et al. · Postgraduate Medicine · 2013
DOI 10.3810/pgm.2013.09.2692
More from this paper
- Achieving a modest weight loss of 5% to 10% significantly improves cardiometabolic risk factors (HbA1c, blood pressure, lipids) and physical functioning in obese patients, even without reaching a normal BMI.Good
- Pharmacotherapy (Orlistat, Lorcaserin, Phentermine/Topiramate) serves as an effective adjunct to lifestyle modifications for patients with BMI >= 30 or >= 27 with comorbidities who fail to achieve adequate weight loss with lifestyle changes alone.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →