Mixed
Higher body mass index (BMI) is independently associated with elevated plasma levels of acylcarnitines (ACs) and large neutral amino acids (LNAAs), serving as biomarkers of metabolic dysregulation and increased cardiometabolic risk.
Your weight (BMI) is a rough proxy for metabolic health, but it's not the whole story. This research shows that as BMI increases, your body's metabolic byproducts (specifically acylcarnitines and large neutral amino acids) also increase, signaling higher metabolic stress and disease risk. Focus on metabolic health markers and lifestyle factors rather than just the number on the scale.
In a multivariable model containing study, race, gender, BMI, and age (Table 2), the AC Factor was independently associated with age (p < .0001) and BMI (p = .014)... every unit (kg/m2) increase in BMI was associated with a 0.015 (SD) unit increase in the normalized AC factor score.
Why this rating
Meta-analysis of 6 diverse studies with 739 subjects, consistent findings across cohorts, but observational nature limits causal inference.
Source
Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations
William E. Kraus et al. · The Journals of Gerontology Series A · 2016
DOI 10.1093/gerona/glw031
Related findings · Mixed
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →