Mixed
Cardiac diastolic function, specifically the E/e' ratio and Left Atrial Volume Index (LAVI), significantly moderates the reduction in relative peak oxygen uptake in Type 2 Diabetes patients.
For T2D patients, standard cardiac checks might miss the root cause of exercise intolerance. If you struggle with exercise despite normal ejection fraction, ask about diastolic function (E/e' ratio). Addressing this through specific training (like high-intensity interval training, as suggested by the authors) may be more effective than generic advice.
Early mitral inflow velocity/early mitral annulus velocity (β coefficient=−1.72, P=0.004) and left atrial volume index (β coefficient=−1.41, P=0.02) were significant moderators of the relative peak oxygen uptake model.
Why this rating
Based on moderator analysis within a meta-analysis; significant p-values but limited by insufficient data for some echocardiographic variables.
Source
Exercise Intolerance in Type 2 Diabetes: A Systematic Review and Meta‐Analysis
Kara C. Anderson et al. · Journal of the American Heart Association · 2025
DOI 10.1161/jaha.124.035721
More from this paper
- Individuals with Type 2 Diabetes (T2D) exhibit significantly reduced cardiorespiratory fitness (CRF), measured as peak oxygen uptake (VO2peak), compared to healthy controls, with reductions averaging 13.9% for absolute VO2peak and 17.4% for relative VO2peak.Strong
- Time since Type 2 Diabetes diagnosis is a significant moderator of absolute peak oxygen uptake, with longer duration associated with greater reductions in fitness.Good
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