Micronutrients & recovery
Zinc supplementation (50 mg oral zinc acetate, 2x/day for 14 weeks) improves insulin secretion specifically in individuals with the SLC30A8 rs13266634 CT/TT genotype, demonstrating a genotype-dependent response to micronutrient intervention.
If you are considering zinc supplementation for insulin resistance, check your SLC30A8 genotype first. If you carry the CT or TT variant of rs13266634, 50mg of zinc acetate twice daily for 14 weeks may significantly boost your fasting insulin levels. If you have the CC genotype, this specific intervention may not offer the same benefit.
In an intervention study, adults and elderly individuals with the CT/TT genotype for the SNP rs13266634 who received 50 mg of oral zinc acetate (2×/day) for 14 weeks showed a 15% (p = 0.04) increase in fasting insulin concentration.
Why this rating
Based on a single intervention study cited; requires replication but has a clear mechanistic basis.
Source
Polymorphisms Involved in Insulin Resistance and Metabolic Inflammation: Influence of Nutrients and Dietary Interventions
Graziela Biude Silva Duarte et al. · Metabolites · 2025
DOI 10.3390/metabo15040245
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