Mixed
High adherence to a Mediterranean diet improves inflammatory biomarkers (triglycerides, hsCRP) in individuals with the TNF rs1800629 GG genotype, demonstrating that dietary patterns can modulate genetic inflammation risk.
If you have the TNF rs1800629 GG genotype, you are genetically predisposed to higher inflammation and triglycerides. Adopting a Mediterranean diet for at least one year can significantly improve these markers, reducing your cardiovascular risk. This is a key example of how diet can counteract genetic inflammation.
Specifically, individuals with the GG genotype from Northern Germany who initially expressed higher TG and hsCRP plasma concentrations showed improvement in these biomarkers after 1 year of dietary intervention
Why this rating
Based on a specific study cited; mechanism is clear but population specificity limits generalizability.
Source
Polymorphisms Involved in Insulin Resistance and Metabolic Inflammation: Influence of Nutrients and Dietary Interventions
Graziela Biude Silva Duarte et al. · Metabolites · 2025
DOI 10.3390/metabo15040245
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