Research
Mixed
Whey protein supplementation (20-40 g/day) combined with resistance training preserves lean body mass and improves strength during GLP-1RA-induced weight loss.
Aim for 1.2-2.0 grams of protein per kilogram of body weight daily. Use whey protein shakes (20-40g) to help meet this goal, especially if you struggle to eat enough solid food. Combine this with resistance training to protect your muscles.
GoodSupportsHIGH confidence
When combined with resistance training, whey protein can help preserve lean body mass during weight loss, with additional strength benefits from creatine monohydrate and β-Hydroxy β-Methylbutyrate supplementation.
Why this rating
Strong mechanistic evidence and data from weight loss populations, though specific GLP-1RA trials are limited.
Source
Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: A narrative review
Brittany V.B. Johnson et al. · Obesity Pillars · 2025
DOI 10.1016/j.obpill.2025.100209
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Omega-3 fatty acid supplementation (≥1 g/day) supports muscle quality, cardiovascular health, and reduces inflammation during GLP-1RA treatment.Good
- Multivitamin supplementation is recommended for individuals using GLP-1 receptor agonists to address micronutrient insufficiencies resulting from reduced caloric intake and gastrointestinal side effects.Moderate
- HMB (3 g/day) and Creatine (5 g/day) supplementation, combined with resistance training, helps preserve lean body mass and strength during GLP-1RA-induced weight loss.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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