Research
Mixed
HMB (3 g/day) and Creatine (5 g/day) supplementation, combined with resistance training, helps preserve lean body mass and strength during GLP-1RA-induced weight loss.
If you are doing resistance training, consider taking 3g of HMB and 5g of Creatine daily. These supplements help protect your muscles and strength while you lose weight on GLP-1RA medication.
ModerateSupportsMEDIUM confidence
When combined with resistance training, whey protein can help preserve lean body mass during weight loss, with additional strength benefits from creatine monohydrate and β-Hydroxy β-Methylbutyrate supplementation.
Why this rating
Based on general weight loss/aging populations, not specific GLP-1RA trials.
Source
Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: A narrative review
Brittany V.B. Johnson et al. · Obesity Pillars · 2025
DOI 10.1016/j.obpill.2025.100209
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Whey protein supplementation (20-40 g/day) combined with resistance training preserves lean body mass and improves strength during GLP-1RA-induced weight loss.Good
- Omega-3 fatty acid supplementation (≥1 g/day) supports muscle quality, cardiovascular health, and reduces inflammation during GLP-1RA treatment.Good
- Multivitamin supplementation is recommended for individuals using GLP-1 receptor agonists to address micronutrient insufficiencies resulting from reduced caloric intake and gastrointestinal side effects.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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