Research
Hormonal
Higher genetically predicted lifelong BMI causally increases all-cause mortality, with the effect substantially mediated through diabetes.
In this population, higher lifelong BMI significantly increases the risk of premature death, largely by increasing the risk of diabetes. Managing weight and blood sugar are critical for longevity.
StrongSupportsHIGH confidence
In this Mexican population, genetically predicted lifelong BMI was strongly related to mortality and mediated substantially through diabetes.
Why this rating
Large sample size (125,003), Mendelian randomization design mitigating reverse causality, and consistent sensitivity analyses.
Source
A Mendelian randomization study of the effect of body mass index on 52 causes of death among 125 000 Mexican adults with admixed ancestry
Louisa Gnatiuc et al. · International Journal of Epidemiology · 2025
DOI 10.1093/ije/dyaf110
cohort · n=125003Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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