Research
Hormonal
Higher genetically predicted BMI causally increases the risk of renal, acute diabetic crisis, and infective deaths.
Higher BMI is strongly linked to death from kidney disease, severe diabetic episodes, and infections. Preventing these outcomes requires addressing underlying metabolic health.
StrongSupportsHIGH confidence
Hazard ratios were greater for vascular-metabolic... and particularly strong for renal... acute diabetic crises... and infective deaths.
Why this rating
Strong statistical significance and large effect sizes for specific causes.
Source
A Mendelian randomization study of the effect of body mass index on 52 causes of death among 125 000 Mexican adults with admixed ancestry
Louisa Gnatiuc et al. · International Journal of Epidemiology · 2025
DOI 10.1093/ije/dyaf110
cohort · n=125003Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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