Hormonal
GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) reduce Major Adverse Cardiovascular Events (MACE) and all-cause mortality in patients with Type 2 Diabetes and established CVD, primarily through weight loss, blood pressure reduction, and anti-inflammatory effects.
If you have Type 2 Diabetes and heart disease, GLP-1 agonists (like semaglutide or liraglutide) are highly effective at reducing the risk of heart attacks, strokes, and death. They work by mimicking a gut hormone to lower blood sugar, promote weight loss, and reduce blood pressure. While they require injections and may cause temporary stomach issues, the heart protection benefits are substantial and well-documented.
Additionally, liraglutide not only contributes to decreasing the incidence of MACEs by 13% and death by 21%, but it seems to reduce all-causes mortality by 15% compared to the placebo in patients with CVD, as revealed by the LEADER trial [55].
Why this rating
Based on large CVOTs like LEADER, SUSTAIN 6, and REWIND.
Source
Cardiovascular Disease and Diabetes: A New Challenge in the Treatment and Management
Graziano Riccioni et al. · International Journal of Molecular Sciences · 2025
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