Hormonal
DPP-4 inhibitors (sitagliptin, saxagliptin, vildagliptin, linagliptin, alogliptin) are cardiovascularly safe (neutral effect on MACE) but do not significantly reduce cardiovascular events or mortality compared to placebo.
DPP-4 inhibitors (like sitagliptin) are safe for your heart and do not increase the risk of heart attacks or strokes, but they also do not reduce these risks. They are a good option for blood sugar control if you cannot tolerate other drugs, but if you have existing heart disease, doctors usually prefer SGLT-2 inhibitors or GLP-1 agonists because those have proven heart benefits.
Clinical trials regarding this class of pharmacological agents examined the incidence rate of MACEs... and documented the absence of statistically significant differences in the group of patients treated with DDP-4 inhibitors compared with patients taking placebo [47–49].
Why this rating
Based on multiple RCTs (TECOS, SAVOR-TIMI 53, EXAMINE, CARMELINA, CAROLINA) cited in the review.
Source
Cardiovascular Disease and Diabetes: A New Challenge in the Treatment and Management
Graziano Riccioni et al. · International Journal of Molecular Sciences · 2025
DOI 10.3390/ijms27010354
More from this paper
- SGLT-2 inhibitors (empagliflozin, dapagliflozin, canagliflozin) significantly reduce cardiovascular mortality and heart failure hospitalizations in patients with type 2 diabetes and established cardiovascular disease, independent of glycemic control.Strong
- GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) reduce Major Adverse Cardiovascular Events (MACE) and all-cause mortality in patients with Type 2 Diabetes and established CVD, primarily through weight loss, blood pressure reduction, and anti-inflammatory effects.Strong
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