Research
Hormonal
Conjugated equine estrogen (CEE) alone does not reduce the incidence of coronary heart disease in postmenopausal women with prior hysterectomy.
If you have had a hysterectomy and are considering hormone therapy for heart disease prevention, current evidence shows it does not work for that purpose. While it may help with bone density (hip fractures), it increases stroke risk. Do not use CEE solely to protect your heart.
StrongRefutesVERY_HIGH confidence
The use of CEE increases the risk of stroke, decreases the risk of hip fracture, and does not affect CHD incidence in postmenopausal women with prior hysterectomy over an average of 6.8 years.
Why this rating
Large-scale, randomized, double-blind, placebo-controlled trial (WHI) with over 10,000 participants and rigorous adjudication.
Source
Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy
Garnet L. Anderson et al. · JAMA · 2004
DOI 10.1001/jama.291.14.1701
rct · n=10739Cited 4,458×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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