Research
Hormonal
Conjugated equine estrogen (CEE) reduces the risk of hip fractures in postmenopausal women with prior hysterectomy.
CEE reduces hip fracture risk, which is a benefit for bone health. However, because it increases stroke risk and does not prevent heart disease, it is not recommended solely for disease prevention.
StrongSupportsVERY_HIGH confidence
The use of CEE... decreases the risk of hip fracture... Hip fracture rates were 11 vs 17 per 10000 person-years (P = .01)
Why this rating
Large-scale RCT with statistically significant result (P=.01).
Source
Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy
Garnet L. Anderson et al. · JAMA · 2004
DOI 10.1001/jama.291.14.1701
rct · n=10739Cited 4,458×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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