Research
Hormonal
Conjugated equine estrogen (CEE) increases the risk of stroke in postmenopausal women with prior hysterectomy.
If you are considering CEE for menopausal symptoms, be aware that it increases your risk of stroke by about 39%. This risk is significant enough that CEE is not recommended for chronic disease prevention.
StrongSupportsVERY_HIGH confidence
The use of CEE increases the risk of stroke... The incidence of stroke was increased by 39% in the CEE group (44 vs 32 per 10000 person-years, z=−2.72, P = .007)
Why this rating
Large-scale RCT with clear statistical significance (P=.007) and crossing of adverse effect monitoring boundary.
Source
Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy
Garnet L. Anderson et al. · JAMA · 2004
DOI 10.1001/jama.291.14.1701
rct · n=10739Cited 4,458×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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