Micronutrients & recovery
Saturated fatty acids contribute to insulin resistance by inducing ceramide synthesis, whereas unsaturated fatty acids do not, and inhibiting ceramide synthesis can ameliorate this resistance.
Prioritize unsaturated fats (olive oil, nuts, fish) over saturated fats (butter, fatty red meat) to potentially lower ceramide levels and improve insulin sensitivity. This is a specific dietary lever within the broader obesity management strategy.
Saturated fatty acids, but not unsaturated fatty acids, induce the synthesis of ceramide, and inhibition of ceramide synthesis ameliorates saturated fatty acids-induced insulin resistance
Why this rating
Cited from specific studies (refs 55, 57) within the review, indicating strong mechanistic evidence in model systems.
Source
Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease
Un Ju Jung et al. · International Journal of Molecular Sciences · 2014
DOI 10.3390/ijms15046184
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