Hormonal
Metformin is the first-line therapy for Type 2 Diabetes, improving glycemic control, increasing insulin sensitivity, and reducing cardiovascular risk and mortality.
Metformin is the standard first-line medication for Type 2 Diabetes. It helps lower blood sugar, improves how your body uses insulin, and uniquely protects your heart and blood vessels, potentially extending your life. It is generally well-tolerated, though some people experience stomach upset initially. It is not suitable for those with significant kidney problems.
Metformin has been proven to be efficacious in lowering blood glucose, increasing insulin sensitivity, reducing cardiovascular [92] and hypoglycemia risk [93], and is the only hypoglycemic agent to improve macrovascular outcomes [94] and to reduce mortality rates in T2DM patients [95].
Why this rating
Cited as a major class with proven efficacy, multiple benefits, and mortality reduction based on extensive clinical use.
Source
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention
Yanling Wu et al. · International Journal of Medical Sciences · 2014
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