Research
Mixed
Genetic or pharmacological ablation of senescent cells extends life span and improves health span in mice by reducing age-related pathologies.
Current research indicates that clearing out aged, non-dividing cells (senolytics) can improve health and extend lifespan in animal models. While human trials are ongoing, the mechanism suggests that targeting these specific cells could help prevent age-related diseases.
GoodSupportsHIGH confidence
recent experimental evidence has shown that the genetic or pharmacological ablation of senescent cells extends life span and improves health span.
Why this rating
Based on multiple genetic mouse models and senolytic drug studies in mice.
Source
Senescence and aging: Causes, consequences, and therapeutic avenues
Domhnall McHugh et al. · The Journal of Cell Biology · 2017
DOI 10.1083/jcb.201708092
narrative_reviewCited 1,218×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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