Research
Mixed
Non-caloric artificial sweeteners (NAS) induce glucose intolerance by altering gut microbiota composition, and these effects can be reversed by antibiotics.
Be cautious with non-caloric artificial sweeteners, as they may negatively impact glucose tolerance by altering your gut microbiome. Opt for whole foods or unsweetened beverages when possible.
GoodSupportsHIGH confidence
While mice drinking water, glucose, or sucrose had similar glucose tolerance curves, all three NAS-consuming groups developed glucose intolerance, which could be reversed upon antibiotic treatment.
Why this rating
Supported by mouse studies and human observational data.
Source
Gut Microbiome: Profound Implications for Diet and Disease
Ronald D. Hills et al. · Nutrients · 2019
DOI 10.3390/nu11071613
narrative_reviewCited 1,109×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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