Mixed
SASP modulation (senomorphics) offers an alternative to senolytics by targeting the secretome rather than killing cells, with potential benefits for wound healing and fibrosis where cell clearance might be harmful.
Instead of killing senescent cells, some therapies aim to reduce their harmful secretions (SASP). Drugs like Metformin and Rapamycin may have these effects, but their benefits are not solely due to SASP modulation. This approach may be safer in contexts where some senescent cells are needed for healing.
Since many of the negative effects associated with senescence are driven by the SASP, compounds that modulate the senescence secretome (often referred to as senomorphics) are an alternative to senolytics (Fig. 4B).
Why this rating
Supported by preclinical models and some human drug repurposing (metformin, rapamycin), but causality of SASP inhibition is often difficult to prove due to multi-target effects.
Source
Senescence and the SASP: many therapeutic avenues
Jodie Birch et al. · Genes & Development · 2020
DOI 10.1101/gad.343129.120
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