Hormonal
Pharmacological inhibition of the TORC1 branch of the TOR pathway using rapamycin extends the life span of adult Drosophila melanogaster.
This study confirms that inhibiting the TOR pathway via rapamycin extends life span in fruit flies. The mechanism involves specific downstream effects on autophagy and translation, not just reduced fertility or insulin signaling. While this is a model organism study, it supports the hypothesis that TOR inhibition is a conserved longevity mechanism.
We show here that feeding rapamycin to adult Drosophila produces the life span extension seen in some TOR mutants.
Why this rating
Controlled in vivo study in a model organism with dose-response data and mechanistic validation.
Source
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov et al. · Cell Metabolism · 2010
DOI 10.1016/j.cmet.2009.11.010
More from this paper
- Rapamycin extends life span in Drosophila specifically through the TORC1 branch by modulating autophagy and protein translation.Good
- Rapamycin treatment increases resistance to oxidative stress (paraquat) and starvation in Drosophila.Good
- Rapamycin extends life span beyond the maximum achieved by dietary restriction (DR) in Drosophila.Good
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