Research
Hormonal
Rapamycin extends life span in Drosophila specifically through the TORC1 branch by modulating autophagy and protein translation.
The longevity benefits of rapamycin in flies are driven by its ability to inhibit TORC1, which in turn increases autophagy (cellular cleanup) and reduces protein translation. This suggests that cellular maintenance and reduced growth signaling are key to longevity.
GoodSupportsHIGH confidence
Analysis of the underlying mechanisms revealed that rapamycin increased longevity specifically through the TORC1 branch of the TOR pathway, through alterations to both autophagy and translation.
Why this rating
Supported by epistasis experiments using mutants (S6K, 4E-BP, Atg5) that block the effect.
Source
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov et al. · Cell Metabolism · 2010
DOI 10.1016/j.cmet.2009.11.010
mechanism_onlyCited 1,096×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pharmacological inhibition of the TORC1 branch of the TOR pathway using rapamycin extends the life span of adult Drosophila melanogaster.Good
- Rapamycin treatment increases resistance to oxidative stress (paraquat) and starvation in Drosophila.Good
- Rapamycin extends life span beyond the maximum achieved by dietary restriction (DR) in Drosophila.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →