Research
Hormonal
Rapamycin extends life span beyond the maximum achieved by dietary restriction (DR) in Drosophila.
Rapamycin extends life span even when dietary restriction (a known longevity intervention) is already maximized, suggesting it works through mechanisms that DR does not fully capture.
GoodSupportsHIGH confidence
Rapamycin could increase life span of... flies with life span maximized by dietary restriction, indicating additional mechanisms.
Why this rating
Direct comparison of life span curves between DR and rapamycin treatments.
Source
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov et al. · Cell Metabolism · 2010
DOI 10.1016/j.cmet.2009.11.010
mechanism_onlyCited 1,096×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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