Research
Energy balance
Weight loss of up to 16% of original body weight is sufficient to improve beta-cell function and insulin sensitivity in adipose tissue, liver, and skeletal muscle by correcting dysregulated gene expression related to lipid and oxidative stress.
Losing up to 16% of your body weight through gradual lifestyle changes (diet and exercise) can significantly improve your body's sensitivity to insulin and improve beta-cell function. This reduction in weight helps reverse the metabolic dysfunction associated with obesity.
GoodSupportsHIGH confidence
A gradual weight loss up to 16% of the original body weight is sufficient to improve β-cell function and insulin sensitivity in AT, liver, and skeletal muscle (Magkos et al., 2016).
Why this rating
Cites specific human studies (Magkos et al., 2016) showing improvement.
Source
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Federica Zatterale et al. · Frontiers in Physiology · 2020
DOI 10.3389/fphys.2019.01607
narrative_reviewCited 1,092×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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