Mixed
Age-related diseases (ARDs) and geriatric syndromes are not distinct entities but represent accelerated aging trajectories driven by the same molecular mechanisms as normal aging.
Focus on interventions that target shared aging mechanisms (like chronic inflammation and oxidative stress) rather than just treating individual diseases as they appear. This approach, known as geroscience, suggests that slowing aging may prevent or delay multiple age-related conditions simultaneously.
we will argue that an integrated hypothesis, fitting most epidemiological and experimental data, is to consider ARDs/GSs as an acceleration of the aging process.
Why this rating
High-quality review paper synthesizing extensive epidemiological and experimental data, though it is a theoretical framework rather than a single clinical trial.
Source
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
Claudio Franceschi et al. · Frontiers in Medicine · 2018
DOI 10.3389/fmed.2018.00061
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