Research
Mixed
Chronic low-grade inflammation (inflammaging) is a key driver of sarcopenia, contributing to muscle protein breakdown and functional decline.
Managing chronic inflammation through lifestyle (diet, stress reduction) may help preserve muscle mass in older adults, in addition to resistance training.
GoodSupportsHIGH confidence
emerging epidemiological and molecular studies indicate that immunosenescence and inflammaging strongly contribute to the pathophysiology of sarcopenia.
Why this rating
Supported by multiple studies cited in the review, though causality is noted as an open question requiring further study.
Source
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
Claudio Franceschi et al. · Frontiers in Medicine · 2018
DOI 10.3389/fmed.2018.00061
narrative_reviewCited 967×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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