Research
Mixed
High-fat, low-fiber diets increase the risk of colon cancer by stimulating secondary bile acid synthesis and suppressing beneficial butyrate production.
Limiting animal fats and increasing fiber helps maintain a healthy balance of gut metabolites, specifically by reducing carcinogenic secondary bile acids and increasing protective butyrate.
GoodSupportsHIGH confidence
these findings suggested two potential mechanisms for diet-associated cancer risk: the protective effect of dietary fibre in increasing butyrogenesis and the promotional effect of dietary fat on stimulating bile acid synthesis by the liver.
Why this rating
Strong mechanistic evidence with reciprocal changes in metabolites and genes.
Source
Fat, fibre and cancer risk in African Americans and rural Africans
Stephen J. O’Keefe et al. · Nature Communications · 2015
DOI 10.1038/ncomms7342
crossover · n=40Cited 967×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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