Energy balance
Modulation of NAD+ metabolism, specifically through the salvage pathway enzyme NAMPT and its product NMN, acts as a metabolic sensor that regulates energy metabolism, oxidative metabolism, and potentially extends lifespan.
Maintaining healthy NAD+ levels is linked to better metabolic function and potentially longevity. You can support this through a diet rich in niacin (Vitamin B3) and its precursors, found in foods like meat, fish, and vegetables. While specific supplements like NMN or NR are discussed in research, the fundamental takeaway is supporting your body's natural NAD+ salvage pathways through balanced nutrition.
Through these effects, NAD+ provides a direct link between the cellular redox status and the control of signaling and transcriptional events. Of particular interest within the metabolic/endocrine arena are the recent results, which indicate that the regulation of these NAD+-dependent pathways may have a major contribution to oxidative metabolism and life span extension.
Why this rating
This is a review paper summarizing multiple studies; it cites clinical trials and animal models but does not present new primary clinical data itself.
Source
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
Riekelt H. Houtkooper et al. · Endocrine Reviews · 2010
DOI 10.1210/er.2009-0026
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- NAMPT (Nicotinamide Phosphoribosyltransferase) is the rate-limiting enzyme in the NAD+ salvage pathway and serves as a critical link between circadian rhythms and metabolism.Moderate
- Sirtuins are NAD+-dependent protein deacetylases that function as metabolic sensors, linking cellular NAD+ levels to downstream metabolic pathways and gene expression.Moderate
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