Research
Energy balance
Sirtuins are NAD+-dependent protein deacetylases that function as metabolic sensors, linking cellular NAD+ levels to downstream metabolic pathways and gene expression.
Sirtuins are proteins that help your cells respond to energy status. They require NAD+ to function. Supporting your overall NAD+ levels through healthy lifestyle habits may support sirtuin activity, which is associated with aging and metabolic health.
ModerateSupportsMEDIUM confidence
Sirtuins are a family of NAD+-dependent protein deacetylases... By their NAD+ dependence, these proteins serve as metabolic sensors in the cell that can regulate downstream metabolic pathways.
Why this rating
Review of existing literature on sirtuin function.
Source
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
Riekelt H. Houtkooper et al. · Endocrine Reviews · 2010
DOI 10.1210/er.2009-0026
narrative_reviewCited 880×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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