Research
Mixed
Excitation-contraction (E-C) uncoupling, specifically involving reduced SR Ca2+ release and reuptake, contributes significantly to the reduction in muscle quality and force production in aging skeletal muscle.
Understanding the cellular mechanisms of aging muscles can help in developing targeted therapies, such as drugs that improve calcium handling, to maintain muscle strength.
GoodSupportsHIGH confidence
One of the causes of this intrinsic reduction in the force-generating capacity of elderly muscle is changes in the excitation–contraction coupling (E-CC) processes... Impairments in SR Ca2+ release have been suggested to explain deficits in physical performance in aged muscle.
Why this rating
Supported by multiple animal studies cited in the review, showing consistent findings on Ca2+ handling deficits.
Source
Skeletal muscle performance and ageing
Michael Tieland et al. · Journal of Cachexia Sarcopenia and Muscle · 2017
DOI 10.1002/jcsm.12238
narrative_reviewCited 877×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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