Micronutrients & recovery
Maternal vitamin B12 deficiency combined with high folate status during pregnancy programs offspring for increased adiposity and insulin resistance by age 6.
For pregnant women, ensuring adequate Vitamin B12 is as critical as folate. In populations with high vegetarianism or low B12 intake, high-dose folic acid supplementation without B12 correction may potentially increase the child's risk of metabolic issues like insulin resistance. Prioritize B12 status alongside folate.
The offspring of mothers with a combination of high folate and low vitamin B12 concentrations were the most insulin resistant.
Why this rating
Prospective cohort study with large sample size (n=700) and rigorous biochemical measurements, though observational design limits causal inference.
Source
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study
Chittaranjan S. Yajnik et al. · Diabetologia · 2007
DOI 10.1007/s00125-007-0793-y
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