Research
Micronutrients & recovery
High maternal erythrocyte folate concentrations during pregnancy are associated with increased offspring adiposity (fat mass and body fat percentage) at 6 years, independent of birth weight.
Monitor maternal folate levels. While folate is essential, extremely high levels in the context of B12 deficiency may contribute to offspring adiposity. Ensure a balanced intake rather than excessive supplementation.
GoodSupportsHIGH confidence
Higher maternal erythrocyte folate concentrations at 28 weeks predicted higher offspring adiposity and higher HOMA-R (both p <0.01).
Why this rating
Prospective cohort with DEXA scans providing precise body composition data.
Source
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study
Chittaranjan S. Yajnik et al. · Diabetologia · 2007
DOI 10.1007/s00125-007-0793-y
cohort · n=700Cited 770×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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