Research
Micronutrients & recovery
Selenium supplementation does not protect against cardiovascular disease or mortality in the general population, despite lower selenium levels being associated with higher risk in observational studies.
Do not take selenium supplements for heart disease prevention. While low levels are associated with higher risk, trials show supplements do not reduce that risk.
GoodRefutesHIGH confidence
In randomized trials, Rayman et al. [63] reported that selenium supplementation did not have a protective effect against cardiovascular disease and mortality.
Why this rating
Based on randomized trials, which are higher quality than observational studies cited for the association.
Source
Selenium in the Environment, Metabolism and Involvement in Body Functions
Youcef Mehdi et al. · Molecules · 2013
DOI 10.3390/molecules18033292
narrative_reviewCited 733×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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