Energy balance
Caloric restriction and fasting-mimicking diets modulate aging pathways (NF-κB, mTOR, MAPK) to reduce pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and counteract inflamm-aging.
Intermittent fasting or caloric restriction may help reduce chronic inflammation in older adults by modulating key aging pathways. However, these approaches require careful planning and may not be suitable for everyone, especially those with poor nutrition.
NF-κB, mechanistic target of rapamycin (mTOR), and MAPK, pathways closely related to aging and inflammation are modulated by caloric restriction that downregulates the activation of IL-1β, IL-6, and tumor necrosis factor (TNF)-α genes, hence the pro-inflammatory state
Why this rating
The paper cites studies on caloric restriction and fasting-mimicking diets but notes they are 'severely limited by their complexity' and 'poor participants compliance'.
Source
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
Anna Aiello et al. · Frontiers in Immunology · 2019
DOI 10.3389/fimmu.2019.02247
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