Micronutrients & recovery
Combining Vitamin D3 with Calcium increases the risk of kidney stones (nephrolithiasis), and active forms of Vitamin D (alfacalcidol and calcitriol) increase the risk of high blood calcium (hypercalcaemia).
Be cautious with combinations. Taking Vitamin D3 along with Calcium supplements may slightly increase your risk of kidney stones. Additionally, active forms of Vitamin D (alfacalcidol and calcitriol) carry a higher risk of causing high blood calcium levels. These risks are statistically significant but should be weighed against potential benefits, especially if you have a history of kidney stones.
Vitamin D3 combined with calcium increased the risk of nephrolithiasis (RR 1.17 (95% CI 1.02 to 1.34); P = 0.02; I2 = 0%; 42,876 participants; 4 trials). Alfacalcidol and calcitriol increased the risk of hypercalcaemia (RR 3.18 (95% CI 1.17 to 8.68); P = 0.02; I2 = 17%; 710 participants; 3 trials).
Why this rating
Statistically significant but based on a limited number of trials for the adverse outcomes.
Source
Vitamin D supplementation for prevention of mortality in adults
Goran Bjelaković et al. · Cochrane Database of Systematic Reviews · 2014
DOI 10.1002/14651858.cd007470.pub3
More from this paper
- Vitamin D3 (cholecalciferol) supplementation significantly reduces all-cause mortality in adults, particularly in elderly populations, whereas Vitamin D2, alfacalcidol, and calcitriol do not show significant mortality benefits.Moderate
- Vitamin D3 supplementation significantly reduces cancer-specific mortality.Moderate
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