Hormonal
High-fat diets increase circulating lipopolysaccharide (LPS) levels (metabolic endotoxemia) through chylomicron-mediated absorption and increased intestinal permeability, leading to subclinical inflammation and insulin resistance.
High-fat meals can trigger gut-derived inflammation (endotoxemia) which contributes to insulin resistance. However, the type of fat matters: emulsified fats (like some vegetable oils) may worsen this effect compared to solid fats (like butter). To minimize this, consider the source and physical state of fats in your diet, and potentially combine high-fat meals with anti-inflammatory foods like flavonoid-rich juices.
Excessive fat intake may favour an increase in circulatory LPS, leading to metabolic endotoxaemia... The greater inflammation observed in individuals with metabolic diseases could be a consequence of the excessive production of mediators by immune cells stimulated by LPS.
Why this rating
The paper is a review citing multiple animal and human studies showing consistent associations, though causality in humans is complex.
Source
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
Ana Paula Boroni Moreira et al. · British Journal Of Nutrition · 2012
DOI 10.1017/s0007114512001213
More from this paper
- Specific fatty acid profiles and the physico-chemical structure of dietary fats (e.g., emulsification) differentially influence postprandial endotoxemia and inflammation, with some unsaturated fats potentially causing higher endotoxemia than saturated fats.Good
- Prebiotics and probiotics can reduce metabolic endotoxemia and intestinal permeability by modulating gut microbiota composition and improving gut barrier function.Good
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