Research
Hormonal
Prebiotics and probiotics can reduce metabolic endotoxemia and intestinal permeability by modulating gut microbiota composition and improving gut barrier function.
If you eat high-fat meals, consider adding prebiotics or probiotics to your diet. Specific bifidobacteria strains can improve gut barrier function and reduce the amount of inflammatory LPS that enters your bloodstream.
GoodSupportsHIGH confidence
An increase in bifidobacteria induced by prebiotic intake reduces endotoxaemia... Bifidobacteria can reduce the levels of endotoxins by improving gut barrier function.
Why this rating
Based on animal and some human studies cited.
Source
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
Ana Paula Boroni Moreira et al. · British Journal Of Nutrition · 2012
DOI 10.1017/s0007114512001213
narrative_reviewCited 638×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High-fat diets increase circulating lipopolysaccharide (LPS) levels (metabolic endotoxemia) through chylomicron-mediated absorption and increased intestinal permeability, leading to subclinical inflammation and insulin resistance.Good
- Specific fatty acid profiles and the physico-chemical structure of dietary fats (e.g., emulsification) differentially influence postprandial endotoxemia and inflammation, with some unsaturated fats potentially causing higher endotoxemia than saturated fats.Good
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