Research
Mixed
Epigenetic clocks based on DNA methylation levels can predict chronological age and the risk of aging-related diseases.
Epigenetic clocks can measure biological age. This can help assess the efficacy of aging interventions.
GoodSupportsHIGH confidence
The level of CpG site methylation with age is a reliable biomarker to predict chronological age. Researchers have developed age estimators called epigenetic clocks based on these mammalian DNA methylation levels.
Why this rating
Well-established concept in the paper with multiple examples (Horvath, Hannum, PhenoAge, GrimAge).
Source
Epigenetic regulation of aging: implications for interventions of aging and diseases
Wang Kang et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01211-8
narrative_reviewCited 629×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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