Hormonal
One week of insufficient sleep (approx. 5.7 hours per 24 hours) disrupts the human blood transcriptome by reducing the number of genes with circadian expression profiles and decreasing their circadian amplitude.
Consistently getting less than 7-8 hours of sleep for even one week changes how your genes express themselves, specifically dampening the natural daily rhythms of immune and metabolic genes. This makes your body more vulnerable to stress and inflammation. Prioritize consistent sleep duration, not just occasional recovery.
Insufficient sleep also reduced the number of genes with a circadian expression profile from 1,855 to 1,481, reduced the circadian amplitude of these genes...
Why this rating
Randomized crossover design with controlled constant routine protocol, though limited to 26 participants.
Source
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome
Carla S. Möller‐Levet et al. · Proceedings of the National Academy of Sciences · 2013
DOI 10.1073/pnas.1217154110
More from this paper
- Prior insufficient sleep significantly increases the number of genes that respond to subsequent acute total sleep deprivation, indicating an intensified stress response.Good
- Insufficient sleep alters the phase and waveform of circadian gene expression, narrowing the window of peak expression for night-active genes and shifting the timing of immune and metabolic gene clusters.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →