Research
Hormonal
Prior insufficient sleep significantly increases the number of genes that respond to subsequent acute total sleep deprivation, indicating an intensified stress response.
If you are already sleep-deprived, staying awake for an extra day (acute sleep loss) triggers a much larger inflammatory and stress response in your blood than if you were well-rested. This suggests that chronic sleep debt makes you biologically more sensitive to acute stressors.
GoodSupportsHIGH confidence
Insufficient sleep... led to an increase in the number of genes that responded to subsequent total sleep deprivation from 122 to 856.
Why this rating
Robust crossover design with controlled constant routine protocol.
Source
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome
Carla S. Möller‐Levet et al. · Proceedings of the National Academy of Sciences · 2013
DOI 10.1073/pnas.1217154110
crossover · n=26Cited 578×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- One week of insufficient sleep (approx. 5.7 hours per 24 hours) disrupts the human blood transcriptome by reducing the number of genes with circadian expression profiles and decreasing their circadian amplitude.Good
- Insufficient sleep alters the phase and waveform of circadian gene expression, narrowing the window of peak expression for night-active genes and shifting the timing of immune and metabolic gene clusters.Good
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